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Author Topic: Drug Interaction?  (Read 888 times)
Vivienne
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« on: April 28, 2012, 07:00:16 AM »

Yesterday I had my last day of Irinotecan with an injection of atropine & some anti sickness tablets in a round of 6. The instructions are that if I get diarrhoea within 24 hrs not to take loperamide but to go back to the centre for another injection.
For the previous 5 chemo days I have done as instructed & not taken any lopermide until well after 24hrs & spent that first evening whilst not having what I would call diarrhoea, having to extremely urgently rush to the loo at least 3 times.  I also struggled to eat a very little dinner.
Last night I am 95% certain that out of habit about a half hour before my dinner when I took my usual paracetamol I forgotmyself & also took the usual 2 loperamide.
My dinner went down easier than on the other 5 chemo nights & I had no urgent calls to the loo.

So my question is why am I instructed not to take loperamide & is there likely to be some reaction I'm not aware of?
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lilianwiles
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« Reply #1 on: April 28, 2012, 12:56:01 PM »

Hello Vivienne,
thank you for your question, and please dont worry, you havent done anything wrong in taking the loperamide.
The reason they advise you not to take the loperamide and to return for another injection of atropine is because the Irinotecan is well known to cause problems with diarrhoea and other related side effects in the first 24 hours or so after it is given. These symptoms are more effectively treated with atropine, rather than with Loperamide, so it is quicker to have the right treatment first time, that struggle on with something that is not necessarily going to help.

If you otherwise feel OK and dont have any other symptoms, then continue on as you would normally do at this stage in your chemo cycle, and get back in touch with your specialist team via their 24 hour contact number if you have any concerns or if you start to feel unwell.

Has this helped?

Best wishes, Lilian
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Lilian Wiles
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Vivienne
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« Reply #2 on: April 28, 2012, 01:59:50 PM »

Thanks Lilian, That is what I thought but felt it best to check.
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Hazel
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« Reply #3 on: April 28, 2012, 11:44:27 PM »

Great ot hear that you ahve had your last cycle of Irinotecan Vivienne and hope you feel better soon!
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Vivienne
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« Reply #4 on: April 29, 2012, 09:21:10 AM »

Thanks Hazel, not feeling too bad at the moment, hope it continues this way as I'm hoping to spend the w/end after next camping near Boscastle with some of my Spiritual/Healer friends. Not if it's anything like this w/end though, how are you faring with the wind & rain?  Gail force with some really heavy gusts down here in Somerset.

Have a good day,  Healing Hugs & Thoughts for all.
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suze
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« Reply #5 on: April 29, 2012, 09:26:16 AM »

hiya vivienne, it certainly is not camping weather atm, is it! Ghastly here in Stoke on Trent .. wet wet wet ... and windy too ..

My wife and sister have gone out running, regardless! I am not going to go out in the wet!
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Sept 2006 Dx. Chemo-rad. to down-size. Jan '07, surgery and ileostomy. March '07-Oct07, 12 cycles of chemo. Jun 08, Ileo reversed.  Oct 09, fresh mets: bowel and lungs. 2nd bowel op. Dec 09-May10, more chemo. 18 months off! Dec 2011, lung mets grew - Jan 2012, lung surgery.
Dec '13 hernia repair
Vivienne
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« Reply #6 on: April 29, 2012, 09:36:18 AM »

I don't think they would do that here Suze, it really is blowing a gail & heavy rain with it. 
I'm still in bed & don't have any inclination to get up although I am starting to feel a little hungry & I somehow don't think my anti sickness packet of ginger biscuits will fit the bill. lol
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suze
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« Reply #7 on: April 29, 2012, 11:16:20 AM »

They are mad, though. Enjoy yr duvet-day!
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Sept 2006 Dx. Chemo-rad. to down-size. Jan '07, surgery and ileostomy. March '07-Oct07, 12 cycles of chemo. Jun 08, Ileo reversed.  Oct 09, fresh mets: bowel and lungs. 2nd bowel op. Dec 09-May10, more chemo. 18 months off! Dec 2011, lung mets grew - Jan 2012, lung surgery.
Dec '13 hernia repair
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